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Biotech / Medical : Antex Biologics (ANTX)

ANTX 1.135

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Dec 31 3:59 PM EST

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To: John R Resseger who wrote (1110)	1/14/1999 11:09:00 PM
From: Amigo Mike	Read Replies (2) of 1476

Small news item ...... New Patent info: 5858352 ISSUE DATE: Jan-12-1999 Vaccine containing a Shigella bacterium having an enhanced antigenic property ASSIGNEE: Antex Biologics Inc. Gaithersburg, MD INVENTOR: Pace; John Lee Germantown, MD Walker; Richard Ives Gaithersburg, MD Frey; Steven Michael Germantown, MD OTHER DETAILS: Legal Rep: Pennie Edmonds LLP Application Date: May-30-1997 Application Number: 866586 Primary Examiner: Naff; David M. ABSTRACT: Methods using in vitro processes are disclosed for inducing or enhancing expression of enteric bacterial antigens or virulence factors. The methods, therefore, produce antigenically enhanced bacteria for use in vaccines. Also disclosed are methods for using the antigenically enhanced bacteria as well as the vaccines containing the enteric bacteria. Specifically, a whole enteric bacteria or components thereof, are provided by Shigella species. In addition to this microorganism there are other enteric bacteria, such as Campylobacter species and Helicobacter pylori, which are useful for inducing or enhancing expression of enteric bacterial antigens and/or virulence factors. Amigo Mike

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