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Biotech / Medical : Monsanto Co.

MTC 2.810

-2.1%

3:06 PM EST

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To: jopawa who wrote (901)	1/15/1999 10:42:00 PM
From: Dan Spillane	Read Replies (1) of 2539

There is YET ANOTHER negative news item floating around. There is supposedly a study which suggests there may be a mechanism which makes Cox-2's (Celebrex, Vioxx) more likely to cause cardiac problems than other NSAIDs. Supposedly all these drugs can cause this problem, but apparently aspirin has yet another mitigating side effect (negates the bad effect). What seems odd about this study is that they seem to compare Cox-2's to ALL NSAIDs in the text of the article, and yet specifically mention an effect of aspirin as something that mitigates that negative effect. So are we really talking about plain old aspirin's known beneficial effect, or is there more to this? In other words, is this relevant to single out the Cox-2's...what about the other NSAIDs vs. aspirin? The other thing about this study is it only suggests a possible mechanism, which the clinical trials haven't shown. I'm a little suspicious given the timing here and feelings of other drug companies concerning Celebrex's approval...

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