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Biotech / Medical : Monsanto Co.

MTC 2.580

-8.5%

Dec 3 3:59 PM EST

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To: Anthony Wong who wrote (903)	1/16/1999 7:01:00 AM
From: jttmab	Read Replies (3) of 2539

It sounds like Dan may be referring to this paper/release: eurekalert.org:80/releases/upmc-ssa011399.html cited on the Yahoo MTC thread. If you poke around the eurekalert site there is a reference that the study was published/included in the proceedings of the National Academy of Sciences. I did a search over at the NAS cite over the most recent publication and did come up with: pnas.org Same author, same subject area...published on the 5th of Jan. The two papers do not seem consistent to me. Specifically, from the end of the abstract, "There was no significant difference between the doses of celecoxib on COX-2 inhibition. Celecoxib and ibuprofen suppressed urinary excretion of the prostacyclin metabolite 2,3 dinor 6-keto PGF1. These data suggest that (i) platelet COX-1-dependent aggregation is not inhibited by up to 800 mg of celecoxib;(ii) comparable COX-2 inhibition is attained by celecoxib (100-800 mg) and ibuprofen (800 mg) after acute dosing; and (iii) COX-2 is a major source of systemic prostacyclin biosynthesis in healthy humans." But I'll have to admit that in this later paper (abstract) I would like to turn to someone with pharmacological expertise for their opinion. Best Regards, Jim

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