PFE (Pfizer) How high will it go? Message Board

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Biotech / Medical : PFE (Pfizer) How high will it go?

PFE 25.54

-0.5%

3:59 PM EST

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To: Anthony Wong who wrote (6720)	1/16/1999 4:55:00 PM
From: John R. Sashko	Read Replies (1) of 9523

The articles are about different arms in the pathways of prostaglandin production. The one states that celebrex doesn't affect thromboxane A2 like motrin does. Thomboxane leads to platelet aggregation and vasoconstriction. Inhibiting a stimulator too much leads to those nasty GI bleeds. But on the other hand, this is what you want to inhibit when you take 2 baby aspirins per day to prevent the annoying MI's & CVA's. The other is about Cox-2 inhibitors affect on prostacyclin. Prostacyclin is an inhibitor of platelet aggregation and causes vasodilation. The concern is that inhibiting the inhibitor may lead to thrombosis. Time will tell if this is a real concern. A big part of the market for Celebrex will be in the geriatric population, where NSAID induced ulcers are frequently silent until they present with the GI bleed. I don't believe that physicians will wait for studies to suggest that their elderly patients should take 2 baby aspirin daily with the Celebrex since they should already be advising it for the males over age 50.

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