Looks like they got a nice spread in
the Times, bold CAPLOCK for the headline
and everything, neat.
I was banging around on the patent server
looking at Ariad patents (they have a hybrid
adeno/adeno-associated vector*) and I thought
I'd look for Targeted Genetics patents, here
are two.
5,736,387
Apr. 7, 1998
The invention provides retroviral vectors which can be used for
directing gene delivery to a specific sub-population of mammalian
cells. The vectors comprise chimeric targeting proteins which
specifically alter the host range of the vector. The chimeric
targeting proteins contain a ligand moiety which is capable of
binding to receptors present on target cells, and an uptake moiety
which is capable of promoting entry of the vector into the target
cell. The ligand moiety is derived from a cytokine that acts upon
the target cells of interest, and the uptake moiety is derived from
a retroviral envelope protein.
5,658,776
Aug. 19, 1997
Adeno-associated virus (AAV) vectors may have utility for
gene therapy but heretofore a significant obstacle has been
the inability to generate sufficient quantifies of such
recombinant vectors in amounts that would be clinically useful
for human gene therapy application. Stable, helper-free AAV
packaging cell lines have been elusive, mainly due to the activities
of Rep protein, which down-regulates its own expression and reverses
cellular immortalization. This invention provides packaging
systems and processes for packaging AAV vectors that efficiently
circumvent these problems by replacing the AAV p5 promoter with a
heterologous promoter and that allow for substantially increased
packaging efficiency.
*think I got that right, it is a bit confusing for newbies.
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