Sepracor-Looks very promising Message Board

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Biotech / Medical : Sepracor-Looks very promising

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To: BMcV who wrote (1656)	1/20/1999 9:17:00 AM
From: Biomaven	Read Replies (1) of 10280

Bruce, On ketoprofen, the following extract from Chiroscience web site is of interest: Background Dexketoprofen was one of the first improved single isomers to be produced by Chiroscience R&D. This was developed in collaboration with Laboratorios Menarini in Spain. Racemic ketoprofen is a well known non steroidal anti-inflammatory drug (NSAID) which has wide use. Utilising the knowledge within Chiroscience R&D of chiral chemistry, biotransformation, molecular biology and production a novel and economic route to the single isomer dexketoprofen was established. Several key process and product patents have been established and a new process using recombinant enzyme has been approved for use in Spain. The entire process from concept to first registration was completed within four years. Dexketoprofen has distinct advantages over the racemic drug since it provides: More rapid absorption and onset of analgesia Lower gastric, upper gastro-intestinal and small intestine damage at an equivalent dose Lower level of deposition within the body fat Haven't heard about much in the way of sales, and surely its prospects will be hurt by Celebrex/Vioxx. On the issue of the ANDRX law suit, that is very much a specific issue in that Hoechst basically paid off ANDRX to keep the generic off the market for longer. Can't see anything comparable happening with SEPR. (Not to say the class-issue vultures won't find someone/something else to sue about, of course.) Peter

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