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Biotech / Medical : XOMA. Bull or Bear?
XOMA 26.09-0.2%Dec 26 3:59 PM EST
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To: Cacaito who wrote (8422)1/22/1999 1:17:00 PM
From: aknahow  Read Replies (2) of 17367
 
Just one minor comment. I don't think anyone implied that the total deaths in and of itself would provide positive proof of statistical significance. To me it meant that at a specified level of total deaths the trial could be ended and at that point statistical analysis would be used to determine if the difference between Neuprex and the placebo was statistically significant.

From the start, it has been made clear that XOMA did not want to run a trial that would go for much more than two years because it just did not have the financial ability to do so. From one point of view halting a a specified level of deaths would permit a quick decision as to significance while meeting XOMA's financial constraints.

The significance of the information coming from XOMA remains that seeking to accrue additional subjects becomes even less of a concern. Remember, some posters were using the continuation of the trial to insist that this meant that Neuprex was ineffective. If there is a total death level, that must be reached, then this is not necessarily the case. In fact, any reduction in deaths due to Neuprex would result in an extension of the trial.

Xoma was at 339 subjects on the 19th. So in any event regardless of which theory is correct, with each day that passes the data becomes more robust.

Please take the time to call XOMA, so you can make a final decision on
this subject.
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