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Non-Tech : NIFTY NINE IN NINETY NINE PLUS ONE
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To: Steve Lokness who wrote (242)1/25/1999 7:48:00 AM
From: Arthur Radley   of 613
 
Steve,
The company that GLGC purchased was Oncormed(ONM). With this purchase they got ONM's repository of human tissue samples specially collected for use in gene-expression studies. This collection will speedup GLGC's development of proprietary databases of gene-expresion information from a variety of normal and diseased human tissues.

GLGC wanted to get into the area that ONM was working and by purchasing the company they were able to speed up the process. Most of the ONM'ed scientific staff made the transfer over to GLGC because GLGC had budgeted before making the offer to acquire them.

Apparently it was ONM that had the alliance with Affymetrix and GLGC is continuing this relationship.

As part of their investor packet, they include a background paper as to how Differential Display Technology works. The utility of differential display is that it allows researchers to compare the bands from different samples--for instance, normal heart muscle and heart muscle from patients with various stages of heart disease. The quantitative differences reveal genes that are either over or under-expressed in the diseased state. These genes may play a key role in the disease process. If one of these genes appears to be suitable drug target, the corresponding cDNA can be obtained from the gel and used to make a probe that will find the gene in a tissue sample. Once the gene is found, its full DNA sequence can be obtained.
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