If orally administered antibiotics are well absorbed, have excellent bioavailability, and provide blood and tissue levels that are virtually the same as those attained by intravenous administration, then there is no difference therapeutically between oral and intravenous antibiotics. . . . Antibiotics that are equally efficacious when administered intravenously or orally (table 3) include doxycycline (Doryx, Vibramycin, Vibra-Tabs), metronidazole (Flagyl, Protostat), trimethoprim-sulfamethoxazole (TMP-SMX) (Bactrim, Cotrim, Septra), clindamycin hydrochloride (Cleocin), minocycline, and the oral quinolones (eg, levofloxacin, ciprofloxacin).
Gee, I was expecting to see Neuprex in the list, but notice it is not. Any comment as to why you think rBPI will not be used because it is only available intravenously? Got some hot news on the pill form of Neuprex?
Agents used in empirical intravenous-to-oral switch therapy at Winthrop-University Hospital, Mineola, New York
Infection: Acute bacterial meningitis
Intravenous agent*: Ceftriaxone sodium
Oral agent*: Chloramphenicol
I again fail to see rBPI. I would spend more time on this, such as comment on the effectiveness of either compound vs. Neuprex, but as Dilbert points out, never argue with an idiot. They drag you down to their level and then beat you with experience.
And it would seem you have too much experience.
|
