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Biotech / Medical : Gene therapy

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To: Mike McFarland who wrote (9)	2/12/1999 7:06:00 AM
From: Mike McFarland	Read Replies (1) of 319

Also regarding Ariad, but has a nice summary of the various vectors: the-scientist.library.upenn.edu The earliest retroviral vectors, based on the murine leukemia virus, carried their genetic passengers into dividing cells--but most of the body's cells are nondividing. Adenoviruses, the same kind of viruses that cause the common cold, had a higher rate of delivery--but the immune system soon kicked the foreign material out of the body. Lentiviruses, such as HIV, promise to incorporate their passenger genes into nondividing cells--but some scientists are skeptical of using a deadly virus for therapeutic purposes. Adeno-associated viruses (AAVs), which cause no known disease in humans, hold equal promise for long-term expression--but they have been difficult to produce in mass quantities. Nonviral vectors cause a relatively small immune response and can deliver larger chunks of DNA than most viral vectors. But they are limited by a low rate of gene transfer and poor long-term expression--especially when delivered in vivo. Most nonviral plasmid DNA vectors give only transient gene expression because they do not integrate.

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