MZ... I know that you remember this. I saw the early data presented at a meeting, but I haven't looked at this manuscript. Nonetheless, it's why I've thought that VEGF alone might not be sufficient for quality vessels.....
Science 1998 Oct 16;282(5388):468-71
Increased vascularization in mice overexpressing angiopoietin-1.
Suri C, McClain J, Thurston G, McDonald DM, Zhou H, Oldmixon EH, Sato TN, Yancopoulos GD
Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to
be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary
for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here
it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more
highly branched vessels. These results raise the possibility that angiopoietins can be used, alone or in combination with VEGF,
to promote therapeutic angiogenesis. |
