Rick, the real reason is that scientists like to be in the cutting edge. CD2, the antigen of 507, is (supposed to be) old hat. While CD40 and even more, CD40L (what is it? CD154??), do sound more like "cutting edge" to me.
More seriously, yes, the literature seems more definite on the role of CD40 on antibody blocking and, in general, blocking that "second signal" (and the CD28/CTLA4/B7 etc for that matter), than on CD2. It also seems to this non-immunologist that several anti-CD40L antibodies have good properties, while not all ant-CD2 ones are created equal, with 507 appearing particularly special. |
