Targretin is a Rexinoid as are LGD1268, LGD1324, and other LGND and AGN second generation compounds.
ERA-327, TSE424, Droloxifene, CP-366,156, Idoxifene, Evista, Tamoxifen are SERMs
Rexinoids compete with Rexinoids
SERMs compete with SERMs
SERMs and Rexinoids don't compete, they synergize
ERA-937 competes with the SERMs above, not Targretin or othe Rexinoids
Combinations will be Rexinoids combining with SERMs, not SERMs with SERMs or Rexinoids with Rexinoids
LGND's current Phase II trial with Targretin combines a SERM (Tamoxifen) with a Rexinoid (Targretin).
Other LGND Breast Cancer trails also combine a Rexinoid (Panretin), with a SERM (Tamoxifen).
I know of no Rexinoid/Rexinoid or SERM/SERM combination trials.
You misunderstanding is at a VERY basic level.
Do you know of any SERM/SERM combos or Rexinoid/Rexinoid combos? |
