Ligand (LGND) Breakout! Message Board

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Biotech / Medical : Ligand (LGND) Breakout!

LGND 199.20

+0.1%

3:59 PM EST

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To: Henry Niman who wrote (28453)	3/2/1999 6:11:00 PM
From: Cacaito	Read Replies (1) of 32384

Could SERMs (like Evista)that promote "good cholesterol" and triglycerides profiles balance out Targretin's "bad" triglycerides changes and allow the combination to be used in breast cancer prevention? for cases of very high risk (women who get surgical removal of the breasts without any disease just for prevention and the like). Later when 2nd and 3rd generation drugs are developed then they will be first option instead of Targretin. Tamoxifen (to my knowledge)has not shown pro-cardiac effects. Evista is already proven to improved the "good" cholesterol, and a large 10,000 patients (and 10 years?)study is ongoing to determine if that translates into actual heart attacks/stroke prevention. Other SERMs (from Lgnd)could prove to be useful the same way as Evista. Other probable markets for SERMs is for men osteoporosis in old age, and men cardiac health prevention (like Evista effects in women).

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