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Biotech / Medical : Pharmacopeia, Inc. (ACCL) (Prev: PCOP)
ACCL 4.050-8.0%Nov 4 3:58 PM EST
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To: kinkblot who wrote (136)3/4/1999 12:56:00 PM
From: kinkblot  Read Replies (1) of 179
 
Medline abstract. Carroll CD et al.,

of the Department of Biology, Pharmacopeia, Inc.

Bioorg Med Chem Lett 1998 Nov 17;8(22):3203-6

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D.

A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1, P2-P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.

ncbi.nlm.nih.gov

...from internal drug discovery programs. A selective plasmepsin inhibitor has been previously reported by PCOP, back in 1996. Perhaps this is a different one. Until they get beyond publishing papers, it's interesting but doesn't do much for shareholders. Now they also have a selective inhibitor against cathepsin D, a closely related enzyme that because of its similar structure, is an important test of specificity.

Inhibitor
for enzyme  / possible treatment for
------------ -----------------------
plasmepsin  / malaria
cathepsin D / cancer, Alzheimers's


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