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Biotech / Medical : Cistron Biotechnology(CIST)$.30

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To: Walter Morton who wrote (2005)	3/7/1999 2:22:00 AM
From: Walter Morton	Read Replies (1) of 2742

IL-1b and TNFa are produced locally within tuberculous granulomas (28,29), and are sufficient to induce formation of granulomas when coupled to inert particles (30). Neutralizing TNFa antibody administered to BCG-resistant mice inhibits the formation of bactericidal granulomas following BCG challenge, and results in progressive, lethal BCG infection (31). These observations closely link granuloma formation, macrophage cytokines, and immunity in animal models of mycobacterial infection. infd21286.infd.cwru.edu

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