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Biotech / Medical : XOMA. Bull or Bear?
XOMA 26.97-1.0%2:01 PM EST

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To: aknahow who wrote (9160)3/12/1999 6:56:00 PM
From: Edscharp  Read Replies (2) of 17367
 
George,

Previous to Xoma and Neuprex has there ever been a phase III trial that used similar criterion as the Neuprex trials? That is, where the protocol included a double-blinded study whose final results were contingent upon the number of deaths of patients.

It occurs to me that if you had a copy of this study (or studies) you might be able to glean invaluable insights into the methodology of DSMB. How many deaths they were looking for, the number of accruals required, etc.

Perhaps someone in Xomaland could be of help in this. It seems likely that when Xoma sat down to discuss protocol with DSMB that someone at Xoma may have done some research on previous protocols.

Of course, if the protocol being conducted on Neuprex is unique then this posting is for naught.

My thought for the day.
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