PFE (Pfizer) How high will it go? Message Board

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Biotech / Medical : PFE (Pfizer) How high will it go?

PFE 24.90

-0.4%

Dec 31 3:59 PM EST

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To: BigKNY3 who wrote (7212)	3/13/1999 10:22:00 AM
From: BigKNY3	Read Replies (1) of 9523

How big is the sexual dysfunction market in female rabbits?.... More evidence that PDE-5's may have a role in Sexual Dysfunction in women. BigKNY3 British Journal of Pharmacology 12/98 Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit Selim Cellek1 & Salvador Moncada The Wolfson Institute for Biomedical Research, University College London, 140 Tottenham Court Road, London W1P 9LN 1Author for correspondence Keywords Nitrergic; nitric oxide; clitoris; corpus cavernosum; rabbit; non-adrenergic non-cholinergic Abstract The corpus cavernosum is the erectile tissue in the penis and clitoris. Although nitrergic neurotransmission has been characterized in detail in the penile corpus cavernosum, functional studies on the inhibitory non-adrenergic non-cholinergic (NANC) transmission in the clitoral corpus cavernosum have been lacking. Here we demonstrate that electrical field stimulation (EFS) induces NANC relaxation responses in the clitoral corpus cavernosum of the rabbit. These responses were inhibited by NG-nitro-L-arginine methylester (L-NAME), 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ) or tetrodotoxin. The inhibitory effect of L-NAME was partially reversed by L-arginine but not by D-arginine. EFS-induced relaxations were enhanced by an inhibitor of type V cyclic GMP phosphodiesterase, zaprinast. These results suggest that nitrergic neurotransmission is responsible for the NANC relaxation responses in the clitoral corpus cavernosum of the rabbit.

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