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Biotech / Medical : XOMA. Bull or Bear?
XOMA 27.25+4.2%Jan 21 3:59 PM EST

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To: Bluegreen who wrote (9349)3/24/1999 2:52:00 PM
From: aknahow  Read Replies (2) of 17367
 
This is my current understand of things I do not understand. Apparently Murphy's 125 was close to the original 130 estimated prior to inclusion of the u.k. is not relevant. Neither is my use of XOMA's accrual number of 200 from the FAQ. Martin has explained to me something close to the following.

The total mortality number is independent of the total accrual number.
That's the whole point of using total mortality events instead of number of
patients accrued. The mortality rate is not based on an accrual number, the
total accrual is an estimate based on an assumed mortality rate.

This is as close as I can get to what was said. I guess one could arrive at a statistically valid p by starting with a death rate assumption for both arms and deriving mortality levels in each arm. Then one would also derive the approximate number of patients that would be in the trial.

I have discovered, or actually rediscovered, there is much I do not understand. If anyone understands this better please post the explanation.
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