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Biotech / Medical : Biogen
BIIB 159.65+2.2%Nov 11 3:59 PM EST
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To: Harold Engstrom who wrote (906)4/2/1999 5:37:00 PM
From: JEB  Read Replies (1) of 1686
 
VLA4 is now on the list for Diabetes. The patent abstract description:

CONCLUSION

In summary, VLA-4 binding agents such as anti-VLA-4 antibodies were protective against diabetes disease onset (Examples 1, 3 and 4) and were effective in delaying the progression of insulitis (Example 2) using a murine model for human diabetes. Other VLA-4 binding agents such as soluble VCAM derivatives (VCAM 2D-IgG) were also useful in protecting against diabetes disease onset (Example 5). The foregoing examples are intended as an illustration of the method of the present invention and are not presented as a limitation of the invention as claimed hereinafter. From the foregoing disclosure, numerous modifications and additional embodiments of the invention will be apparent to those experienced in this art. For example, actual dosage used, the type of antibody or antibody fragment used, mode of administration, exact composition, time and manner of administration of the treatment, and many other features all may be varied without departing from the description above. All such modifications and additional embodiments are within the contemplation of this application and within the scope of the appended claims.

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