Slugger> I would venture a guess that the underpowered 130 target was assuming the lack of potential usa accruals. I bet the uk changed that equation to a targeted mortality number then estimated to be 200 to obtain a reasonable power. Just my guess.
Bluegreen>there are lots of host defense proteins and peptides, and we fall "generally" into the larger protein category. But again even if its not us (probably not), its still a further confirmation of the bpi line of R&D.> IMO if you look at all the host defense molecules ,all attributes,
nothing comes close. If you look at individual properties, certainly a better this or better that can always be found or made. Remember,
bpi "may" affect a whole range of human systems. IMO its the range and the synergy of the molecules systemic effects that make bpi unique. For example>ATIII. It targets ONE human system.(in general) Perhaps better than bpi perhaps not. >BPI "perhaps" targets the same general system and many others in concert. I have said and maintained many times that their are probably 4 or 5 reasons why bpi
"may" work in meningo. Might be just one reason, might be a combination of reasons, or might not work at all. The human body has lots of build in redundancies , and this is the reason for so many failed trials to date. Bpi is a molecule might be able to deal with redundancies in its own unique way (or perhaps not)
In summary I dont think anyone really knows what effects the combination of bpi properties will do given various scenarios. I think xoma is doing a excellent job of trying to figure it out via broad testing and research.
My personal feeling always comes back to the fact that bpi21 is based upon a NATURAL human protein, and is there for a reason for bpi to be naturally within us..
The fact that within bpi contains coding for a range of activities and actions,(antifungal,antiangio,anti-endo,etc,etc......) leads me to believe that halo bpi is some sort of master molecule in our bodies that has actions across many human systems.
IMO we just need understand it and to tame its power.
All disclaimers always apply to all my notes. Treat nothing as fact.
Never invest based on what I say. Treat as worthless reading.
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