Stuart:
Thanks!
OK, if this is correct, it looks like big days on both Sunday (ovarian, pancreatic) and Tuesday (rhabdo). The data that is most impressive, IMO and from the abstracts, is that due on Tuesday. However, the xenograft data that is to be presented on Sunday represents "big market" models. I had hoped to review the abstracts in the thread by now, but never got around to it. I suspect that all the thread regulars have been keeping their mouths shut and buying.
For those who have not looked at the abstracts, they include 100% inhibition of tumor growth for both rhabdo (RH30) and pancreatic. Controls are Taxol for ovarian, Gemcitabine for pancreatic, and Cisplatin for rhabdo. The 114 results make the controls look silly.
The data seems to be presented in a conservative fashion, as one table indicates eight of nine partial responses and no complete responses for rhabdo RH1 where the growth inhibition is listed as 99%.
That's the eye-grabbing stuff. The mechanistic studies and work with chemoresistant tumors is even more impressive, IMO. Dr. Kelner seems to still be moving and shaking, and I'm interested in hearing more about the newer derivatives of illudin (or, formally, acylfulvene??).
But.... the observation that really blew me away was that there would be a poster on phase II prostate at ASCO.
Rick |
