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Biotech / Medical : Ionis Pharmaceuticals (IONS)

IONS 82.68

-1.4%

Jan 30 3:59 PM EST

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To: tom jones who wrote (2544)	4/12/1999 7:43:00 PM
From: sim1	Read Replies (1) of 4676

I happen to have their Event Locator close at hand... All records where title contains "tomudex" PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (P) Biological Approaches I: Antisense Oligonucleotides and Receptor Antagonists Apr 11 1999 8:00AM "Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of Tomudex, 5-FU, 5-FUdR, and methotrexate in HeLa cells." Apr 11 1999 8:00AM "Effects of antisense oligodeoxynucleotides (ODNs) targeting against thymidylate synthase (TS) on the growth and Tomudex sensitivity of human tumor cell lines in vivo." CLINICAL RESEARCH (P) Gastrointestinal Cancer I: Colorectal and Hepatobiliary Cancers Apr 12 1999 1:00PM "Activity of the combination tomudex + irinotecan in human colon carcinoma cells resistant to fluorouracil." Phase I Clinical Trials Apr 11 1999 8:00AM "Influence of tomudex on the pharmacokinetics of 5-FU and its metabolism: A phase I trial."

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