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Biotech / Medical : T/FIF Portfolio

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To: Biotech Jim who wrote (802)4/17/1999 1:19:00 PM
From: scaram(o)uche  Read Replies (2) of 1073
 
David, BJ:

OK, we have some cash in "dry-powder". I'll add NBIX. Please note that, for this portfolio, I don't get fancy and use the current ask for purchases..... I just go to the SI portfolio and use whatever price is given at the time. If a stock gaps, I'll go back and either edit out the purchase or enter the opening ask.

New CSO? Urrrrrrggggggggghhhhhhhh...... I hate surprises. I thought that Paul Conlon had been doing a bang-up job. Not enough neuro background? This would be a "new" slot, correct? Not a replacement?

Regarding the CRF 1 receptor antagonist....... here's the update from the recent 10-K......

Neurocrine and its corporate partner are developing small molecule
therapeutics to block the effects of overproduction of CRF for the treatment of
depression. The Company has developed several distinct chemical series of CRF
receptor antagonists. Janssen selected a drug candidate in 1996 for preclinical
testing and commenced Phase I clinical trials on the compound in late 1997 and
completed these in 1998. In late 1998 a Phase II open label trial was initiated
in patients with major depression. Results from this trial are expected to be
available in second half of 1999. No assurance can be given that Janssen will
successfully complete Phase II clinical testing of this candidate or that the
Phase II data will support continuation of the program and additional clinical
trials.


Rick

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