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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ)

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To: Tim Davies who wrote (21288)	4/23/1999 8:01:00 PM
From: DaiS	Read Replies (2) of 23519

Tim, Alibra is a new version of Muse that will make viagra obsolete In Alibra the pellet contsins two drugs alprostadil and prazosin - Muse has only the former Alibra testing is now in phase III, approval soon. Prazosin like alprostadil is an approved drug, thus it is unlikely that approval for alibra will not be given (this example of Vivus strategy of focusing on already approved drugs) One journal publication and the AUA and Amsterdam conference abstracts indicate that Alibra is more effective overall than Muse. The inclusion of prazosin the pellet makes Alibra suitable for psychogenic ED sufferers as well as organic sufferers. Thus Alibra will compete better than Muse with Viagra in certain patient groups. Because there will be only 125ug of alprostadil in the pellet, pain will be reduced and eliminated in many users will thus be eliminated. Lower alprostadil will reduce side effects, such as hypotension and occasional fainting - this supported by published evidence. A smaller pellet might result in less discomfort as it is dispersed in the urethra An improved sexy applicator It has been said that alibra can be stored at room temperature. No tricky questions "what's this in the fridge Mom" ((NB, muse retains activity for up to two weeks at room temperature - see vivus.com. It is possible that admixture with prazosin stabilises alprostadil. There is evidence that stability of alprostadil is affected in mixtures.) Only single dose, thus no embarrassing titration with doctor needed. Because of low alprostadil content it could be marketed profitably at perhaps 25% or less of the cost of muse. Alibra provides Vivus with excellent bargaining position for partner/buyout because Astra Janssen do not have alibra distribution rights! We have to believe that it will be marketed by a large experienced company! There is even the possibility that Alibra will be OTC DaiS

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