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Biotech / Medical : VVUS: VIVUS INC. (NASDAQ)

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To: DaiS who wrote (21361)	4/26/1999 5:17:00 PM
From: Edderd	Read Replies (1) of 23519

DaiS Besides the discomfort of the congestion caused by the alprostadil the biggest drawback to MUSE is the distance the applicator has to be put into the urethra. Over 1 ". Thats why I mentioned the gel as a technique whereby the material could be squirted into the Fossa Navicularis and then easily massaged back into the urethra to be absorbed. At one time a local pharmacy was producing a liquid alprostadil for patients to use by squirting it into the urethra and getting good results (not tested). A smaller diameter inserter would IMO be a setback because it would be too sharp and patients could hurt themselves during insertion. Shorter would be good however. All IMO Ed

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