Graham, thanks for mentioning cationic peptides. I did a search on patent.womplex.ibm.com and found some hits for cationic and peptide; patent 5459235, assigned to regents of u.calif.
Unfortunately, this does not lead us to micrologic biotech! The only other cationic peptide patent was 5120829, also in Calif, for a Cancer lab.
The 5459235 patent referenced no other, nor has it been referenced itself. This indicates it is either too new, or not deemed a core patent. It builds on no other patent, which could mean it is something unique.
There were no patents assigned to Micrologic, nor to Hancock, on the database.
Fred Bealle, Toronto
Here is the patent abstract & 1st claim:
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5459235 : Antimicrobial peptides antibodies and nucleic acid molecules from bovine
neutrophils
INVENTORS:
Selsted; Michael E., Irvine, CA
Cullor; James S., Woodland, CA
ASSIGNEES:
The Regents of the University of California, Oakland, CA
ISSUED:
Oct. 17, 1995
FILED:
Mar. 19, 1993
SERIAL NUMBER:
033873
FEE STATUS:
INTL. CLASS (Ed. 6):
A61K 37/02; C07K 15/28; C07H 17/00;
U.S. CLASS:
530-300; 530-387.9; 536-023.5;
FIELD OF SEARCH:
530-324,305,333,388.1,387.9,388.85,389.1,300 ; 536-23.5 ;
AGENTS:
Campbell and Flores;
ABSTRACT: The present invention provides a new family of cysteine-rich antimicrobial peptides isolated from bovine neutrophils herein
named beta defensins. Thirteen structurally homologous peptides were purified to homogeneity from a granule-rich cytoplasmic fraction of
purified blood neutrophils. These antimicrobial compounds are useful in human and veterinary medicine, and as agents in agricultural, food
science, and industrial applications.
U.S. REFERENCES: none
No patents reference this one
6 CLAIMS: First Claim Shown (Show all claims)
We claim:
1. A substantially purified .beta.-defensin peptide having antimicrobial activity selected from the group conisting of the peptides
having any one of the sequences corresponding to Sequence ID numbers 1 to 13.
RELATED U.S. APPLICATIONS: none
FOREIGN REFERENCES: none
OTHER REFERENCES:
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PRIMARY/ASSISTANT EXAMINERS: Lacey; David L.; Loring; Susan A.
ADDED TO DATABASE: Aug. 23, 1996 |
