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Strategies & Market Trends : Biotechnology Cancer Cures
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To: tnsaf who wrote (55)5/21/1999 3:50:00 PM
From: Mike McFarland  Read Replies (1) of 226
 
Scientists at the University of North Carolina
at Chapel Hill have discovered the molecular role
in cancer development of a mutated tumor suppressor
gene known as ARF.

eurekalert.org
"So we tested whether mutations derived from cancer
patients would mislocalize ARF and impair its ability to
block p53 export and degradation. The answer is yes,"
Xiong states. "With ARF mutated and mislocalized,
oncogenes go unchecked and cells proliferate abnormally,
initiating oncogenesis."
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