Building Detailed Map Of Human DNA Will Take
More Time And Resources Than Previously Thought,
Says Hutch Researcher
eurekalert.org
"For geneticists, part of the appeal of isolated populations such as Iceland was that you might be able to get away with a much looser genetic map containing fewer SNPs, or genetic markers," he says. "However, my research shows that in regions surrounding common genetic mutations, the DNA from Iceland looks exactly the same as that from larger populations, requiring an equally dense map of SNPs to detect an association between a marker and disease."
To be truly homogenous, or free of "background noise," a population must be founded by fewer than 100 people, Kruglyak estimates. Iceland, in contrast, sprung from a migration of more than 10,000 people. |
