To: Koda Ridge who wrote (9262 ) 6/23/1999 1:11:00 PM From: DR. MEADE Respond to of 108040
APPI .041 x .043 ***** Company Homepage and 1999 PR's via Yahoo: advancedplantpharm.com biz.yahoo.com All Company PR's From Company Web Site: advancedplantpharm.com APPI Financial and Stock Numbers From USAShares.Com: usashares.com APPI's Patent For LoChol via IBM Patent Search: (Patents Pending For Leuknil and LMH-123) patents.ibm.com Online E-Commerce Sites Linking or Selling APPI Products: Shop Now.Com (Go to Personal Care:Vitamins/Supplements or Search) shopnow.com Free Ride.Com (Take the tour, go to "Get It" Online Sites) freeride.com Adatom.Com (Search or by category or room) adatom.com Sell 'Em.Com (Go to Health & Beauty Section): sellem.com APPI Message Boards: ragingbull.com Subject 4850 Company Profile (As of 4/99) Advanced Plant Pharmaceuticals, Inc., (APPI) is a pharmaceutical company dedicated to utilizing whole plants to develop products for the treatment of human diseases. APPI has developed and protected a unique method of manufacturing such products which has allowed the Company to receive the first IND for a whole plant pharmaceutical. The products and manufacturing processes are protected by composition patents and trade secrets. The Company's roots began in Australia in 1987, as a research program to study the use of whole plants as a source of pharmaceutical products to enhance the immune system and to combat debilitating diseases, such as AIDS. The founders believed that plants would provide a safer and less expensive product with fewer side effects than chemical based compounds. APPI has expanded its efforts beyond the immune system. Patents are pending for products used to treat AIDS, Leukemia, cancer, and Alzheimer's disease. The Company has also developed a whole plant product, LoChol, for use as a natural cholesterol reducing remedy which will be marketed in1999, as a nutritional supplement. The Company's most clinically advanced pharmaceutical is a unique natural product, Abavca/Perthon (called Abavca), derived exclusively from whole plants. Abavca has been demonstrated to overcome many of the debilitating symptoms of the AIDS virus while enhancing the immune system. This is accomplished at significantly less cost than the current treatment protocols for this disease. In 1994, APPI was given an IND(investigation new drug) for Abavca from the U. S. Food and Drug Administration. The Company will be starting a Phase I/II clinical trial at a major New York metropolitan teaching hospital in early 1999, in order to begin the commercialization of this product. The Company also has submitted patents on Leuknil, a whole plant product to be utilized for the treatment of Leukemia and cancer and LMH-123 for the treatment of Alzheimer's disease. These products, along with LoChol (link to patent above), are the first products that APPI will seek to develop and distribute internationally. In January and February of 1999 APPI inked agreements with Sell 'Em.Com, Free Ride.Com, and ShopNow.Com to link and/or sell APPI's products online. In March of 1999, APPI signed an agreement to be a store site at Adatom.Com, often referred to as the "Amazon" of online catalog sites. In April of 1999 APPI announced the spin-off of a subsidiary that will develop a vitamin and nutritional online superstore where customers can buy APPI and other select vitamin products as well as receiving links and online information to vitamin and nutrition resources. As this spin-off expands APPI plans to franchise rights to international distributors. Company Financial & Share Information (From USAShares.Com as of 12/98) (This information is in process of being verified via e-mail to USAShares as of 4/26/99.) Common Shares Outstanding: 47,000,000 Estimated Float: Approx. 30,000,000 Market Capitalization: $2,820,000 52 week high: $.14 52 week low: $.02 Contact Information Telephone: 212 402-7878 FAX: 212 402-7879 Advanced Plant Pharmaceuticals, Inc 75 Maiden Lane 3rd. floor New York, N.Y. 10038 E-mail: appi@erols.com