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Biotech / Medical : Neurobiological Tech (NTII) -- Ignore unavailable to you. Want to Upgrade?

To: Mike McFarland who wrote (594)	6/23/1999 3:52:00 PM
From: Mike McFarland	Read Replies (1) \| Respond to of 1494

And the last batch from Eurkalert for the day: New enzyme tied to tangles in Alzheimer's disease eurekalert.org Pin1 may play a role in the formation -- or prevention -- of tangles. NYU scientists discover gene for a dementing brain disease eurekalert.org The mutation caused more amino acids to be added onto the protein. In fact, instead of a protein of 266 amino acids, the mutation caused a larger protein of 277 amino acids to be produced. The amyloid protein found deposited in the brain of patients with Familial British Dementia consists of the last 34 amino acids snipped from the larger protein. The NYU group believes the precursor protein sticks out through the outer cell membrane and is cut by special enzymes, producing the amyloid fragment. The amyloid beta protein associated with Alzheimer's disease is generated by a similar mechanism; namely, a larger protein called amyloid precursor protein or APP sticks out from cell membranes and the amyloid fragment is formed by specific enzymatic degradation of this precursor protein. Due to the similarities between Alzheimer's disease and Familial British Dementia, the NYU School of Medicine group hopes that the discovery may shed light on the pathological mechanisms underlying Alzheimer's and other dementias. and another FBD link eurekalert.org