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Biotech / Medical : Sepracor-Looks very promising -- Ignore unavailable to you. Want to Upgrade?

To: David Howe who wrote (3377)	6/29/1999 2:10:00 PM
From: Don Miller	Respond to of 10280

Scott it works better, the only question is pricing and the market size. See today's #3375 on this BB and from yahoo and Yahoo club An asthmatic now using xopenex by: rljacobson 6106 of 6253 I am a retired chemical engineer fighting asthma for 45 years. I have been using xopenex since may 20th. My peak outlet flow is holding above 320 L/min 6 hours after taking xopenex. My maximum flow is 390 L/min holding at 350 L/min for several hours. Previously I was taking albuterol and atrovent. After 5 hours my flow rate often got down to 250 L/min. A stiking diference is that I am not taking an airway dilator in early morning. I am waking up at 7AM still breathing comfortably. I can not make a direct comparison between xopenex and albuterol because they are supplied diferently. I need xopenex suppied in a canister for convenient use in the same type of package as albuterol is supplied. Posted: 06/03/1999 02:18 pm EDT as a reply to: Msg 6104 by millerd1_airmail_net _________________________________________ to millerdl by: rljacobson 6118 of 6253 I take xopenex about every 6 hours which is near end of its dilation effect. However I am lasting through the night which is unusual for me. I am retired from Chevron and am on medicare and Chevrons United Health care. I copay 8$ per 24 3cc ampules. I often take one half of the .63 Mg at a time. That gets me to 390 L/min about my maximun with albuterol only. Addition of atrovent will increase flow rate some. With xopenex I am having no low flow rates following depletion of the drug activity. I believe albuterol has a residual deliterious effect at the end of its effectiveness. Because of this effect I have been using it sparingly,along with atrovent sparingly. I am concerned about the high dose of xopenex. I would like to have xopenex available in the canister application in 50 mcg puffs similar to albuterol in 90 mcg puffs. I could then make replicatable comparisons. Posted: 06/04/1999 12:51 am EDT as a reply to: Msg 6110 by millerd1_airmail_net _______________________________________________ From Yahoo club: #841 rlj33 (66/M/valley springs ca) 06/07/1999 01:44 pm EDT I have been taking xopenex since May 20. My peak flow rates are increased from 320L/min to 400 L/min which is my max with only one half the 0.63 Mg dose. When I was using the metered doses of albuterol my flow dropped below 300L/min following depletion of its effectiveness. I could make a direct comparison if I had xopenex available in the MDI at a level comparable to the 90 mcg/puff application. I believe that albuterol contains ingredients that decrease my peak flow rates following depletion of its expansionary effect.