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Biotech / Medical : T/FIF Portfolio -- Ignore unavailable to you. Want to Upgrade?

To: LLCF who wrote (1014)	6/29/1999 7:57:00 PM
From: sim1	Read Replies (1) \| Respond to of 1073

An upcoming Nature article on a Warner-Lambert discovery. Any significance here? Warner-Lambert Researchers Say Compound Stalls Tumors in Mice Washington, June 28 (Bloomberg) -- Warner-Lambert Co. researchers have discovered a new drug that stalls the growth of cancerous tumors in mice, according to a study to be published tomorrow. The experimental compound, which hasn't yet been tested in humans, inhibited the growth of tumors by 53 percent to 79 percent in mice that were given varying doses. The research will be published in the July edition of the journal Nature Medicine. The drug, called PD 184352, works by stopping a cellular pathway called MAPK, which is responsible for a variety of different functions, including normal, healthy cell division. In some kinds of cancer, MAPK is over-stimulated, prompting cells to grow out of control. In an accompanying editorial, three researchers from the National Cancer Institute and the Van Andel Research Institute said the data ''show the importance of this pathway as a target in the war against cancer.'' The drug may also act in a similar way to anti-angiogenesis drugs, a promising class of drugs that stops tumor growth by cutting off a tumor's ability to grow blood vessels. MAPK plays a role in the growth of blood vessels, the process known as angiogenesis. The drug could run into problems because of the wide variety of processes that use the MAPK pathway. Inhibiting MAPK might important cellular functions, in addition to hindering tumor growth. Morris Plains, New Jersey-based Warner-Lambert shares fell 7/16 to close at 62 3/4.