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To: Tupulak who wrote (56)7/7/1999 9:21:00 PM
From: tnsaf  Read Replies (1) | Respond to of 164
 
A little old
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Monday June 7, 1:00 pm Eastern Time

Company Press Release

SOURCE: Ophidian Pharmaceuticals, Inc.

Ophidian Expanding Clinical
Development and Drug Applications of Its Core
Antibody Technology

SAN FRANCISCO, June 7 /PRNewswire/ -- Ophidian Pharmaceuticals, Inc. (Ophidian)
(Nasdaq: OPHD; Pacific Exchange, Inc.: OPD), disclosed today that it is moving ahead with its
plans to begin Phase II clinical testing of its lead drug, OPHD001, for Clostridium
difficile-associated disease. This trial is planned to begin this summer. The company also
disclosed its plan to submit an Investigational New Drug to the Food & Drug Administration by
the end of the first quarter of 2000 for approval to begin clinical trials for a second
gastrointestinal product, OPHD002. OPHD002 is an oral anti-cytokine antibody formulation
designed for the treatment of inflammatory bowel disease. Douglas Stafford, Ophidian's
President and Chief Executive Officer, made these statements at the 11th Annual International
Life Sciences Partnering Conference hosted in San Francisco. This conference is an
international forum to promote strategic partnerships among biotechnology and pharmaceutical
firms for the development and commercialization of new drug products.

Mr. Stafford said, ''We have learned a great deal about orally-delivered antibodies through the
development of OPHD001. From this knowledge and extensive new laboratory studies, we
have found that the oral delivery of our avian antibodies is effective in treating inflammatory
intestinal diseases in animals. This creates a new significant therapeutic application for our core
technology in the area of inflammatory bowel diseases.'' The company's technology allows for
topical delivery of therapeutic antibodies to diseased regions of the intestinal tract with oral
dosing techniques. ''The topical delivery is a unique strategy to localize the drug effect to the
intestinal tract without side effects associated with systemic administration,'' he added.

This document may contain certain forward-looking statements based on current management
expectations. There are certain key factors that could cause future results to differ from those
anticipated by management. Such factors include, but are not limited to, technical risks
associated with the development of new products, the continued progress of clinical trials of the
company, the company's ability to continue to establish collaborative agreements with third
parties, the competitive environment of the biotechnology and pharmaceutical industries, and
general economic conditions. Additional information on potential factors that could affect the
company's financial results are included in the company's prospectus dated 7 May 1998, and
other reports filed with the Securities and Exchange Commission.

SOURCE: Ophidian Pharmaceuticals, Inc.