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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Cacaito who wrote (10789)	7/14/1999 5:04:00 PM
From: Pseudo Biologist	Read Replies (2) \| Respond to of 17367

Thanks, Cacaito, great post. But, your are too fast for me; let me ask a couple of questions if you don't mind. <<The bactericidal property of bpi was determined by blood culture colony count (nice trick)but they killed the monkeys at 72 hours?>> I've read elsewhere (e.g. the recent Science article on HMG-1 mentioned by Peter last week), that sepsis or sepsis-like conditions can take a few days to develop fully, at least in humans. Is your concern here that 72 hours was too short a period and that the authors of the study may be missing something by stopping the experiment at this stage? <<The monkey sepsis model is very drastic, infusing lots of bacteria in the veins, it was modified for the bpi experiment.>> Modified to make it less drastic?? <<but they also proof much lower levels of citokines,tnf,paf (down regulation of the inflammatory pathway)...>> Interesting indeed, if BPI is not doing this by reducing LPS levels, by what mechanism is this happening? Or can one track everything back to simply killing the bacteria perhaps more rapidly than possible with other antibiotics (thanks bluegreen for that insight)? Thanks again for sharing your thoughts on the work of (the late) Dr. Schlag and his colleagues. PB

To: Cacaito who wrote (10789)	7/14/1999 7:44:00 PM
From: Robert K.	Read Replies (1) \| Respond to of 17367

Cacaito, from my previous post"The theory from the baboons study (which still may be incorrect)( I still have doubts), is that bpi is beneficial for its antibacterial effects (primarily) and NOT for its anti-endotoxin actions" That exactly my point, they claim antibacterial, but who knows. As you say>"I agree the main activity is to kill bacteria, but the second property is the one I am investing in Xoma, downregulation of the inflammatory chain." I am glad you see that too. BTW-I was hoping you would comment on the post cause I value your opinions greatly, and I know if I slip up you will be right there :-) And agreed, nothing quite like bpi. IMO.