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Non-Tech : Bill Wexler's Dog Pound -- Ignore unavailable to you. Want to Upgrade?

To: Bill Wexler who wrote (2645)	7/30/1999 3:11:00 PM
From: DanZ	Read Replies (3) \| Respond to of 10293

Mr. self-proclaimed scientific expert, Bill Wexler, says Zicam is a "scientific fraud". You obviously need an education in the relationship between zinc, ICAM receptors, and the common cold. I invite you to go to zicam.com for some well needed readings. Would you please post your biography with respect to education, research, papers written, etc... so we will know where you obtained your profound expertise of zinc, ICAM receptors, and the common cold. Here is what you will find in case you are too lazy to go to the link. If you go to the link, you will find that they provide hyperlinks to each of the articles. RELATED SCIENTIFIC ARTICLES REVIEW ARTICLES Novick SG, et al. How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action. Med Hypotheses. 1996 Mar;46(3):295-302. Novick SG, et al. Zinc-induced suppression of inflammation in the respiratory tract, caused by infection with human rhinovirus and other irritants. Med Hypotheses. 1997 Oct;49(4):347-57. Rossmann MG. Viral cell recognition and entry. Protein Sci. 1994 Oct;3(10):1712-25. van de Stolpe A, et al. Intercellular adhesion molecule-1. J Mol Med. 1996 Jan;74(1):13-33. PEER REVIEW ARTICLES -------------------------------------------------------------------------------- Korant BD, et al. Zinc ions inhibit replication of rhinoviruses. Nature. 1974 Apr 12;248(449):588-90. Geist FC, et al. In vitro activity of zinc salts against human rhinoviruses. Antimicrob Agents Chemother. 1987 Apr;31(4):622-4. Merluzzi VJ, et al. Evaluation of zinc complexes on the replication of rhinovirus 2 in vitro. Res Commun Chem Pathol Pharmacol. 1989 Dec;66(3):425-40. Godfrey JC. Zinc for the common cold. Antimicrob Agents Chemother. 1988 Apr;32(4):605-6. Greve JM, et al. The major human rhinovirus receptor is ICAM-1. Cell. 1989 Mar 10;56(5):839-47. Staunton DE, et al. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Cell. 1989 Mar 10;56(5):849-53. Staunton DE, et al. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell. 1990 Apr 20;61(2):243-54. Casasnovas JM, et al. Kinetics and thermodynamics of virus binding to receptor. Studies with rhinovirus, intercellular adhesion molecule-1 (ICAM-1), and surface plasmon resonance. J Biol Chem. 1995 Jun 2;270(22):13216-24. Huguenel ED, et al. Prevention of rhinovirus infection in chimpanzees by soluble intercellular adhesion molecule-1. Am J Respir Crit Care Med. 1997 Apr;155(4):1206-10. Terajima M, et al. Rhinovirus infection of primary cultures of human tracheal epithelium: role of ICAM-1 and L-1beta. Am J Physiol. 1997 Oct;273(4 Pt 1):L749-59. Bella J, et al. The structure of the two amino-terminal domains of human ICAM-1 suggests how it functions as a rhinovirus receptor and as an LFA-1 integrin ligand. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4140-5. Wickham TJ, et al. A simple model to predict the effectiveness of molecules that block attachment of human rhinoviruses and other viruses. Biotechnol Prog. 1995 Mar-Apr;11(2):164-70. Nagase T. The role of intercellular adhesion molecule-1 in respiratory disorders. Nihon Kokyuki Gakkai Zasshi. 1998 Nov;36(11):923-7. Gern JE, et al. Association of rhinovirus infections with asthma. Clin Microbiol Rev. 1999 Jan;12(1):9-18.