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Biotech / Medical : Biotransplant(BTRN) -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (371)	8/25/1999 1:42:00 AM
From: margie	Read Replies (1) \| Respond to of 1475

Congratulations, Richard! Hope Biotransplant and Mass General Hospital TBRC get at least some of the excitement and attention accorded Entremed for their "cure" of cancer in mice. Remarkable results! BTRN's and Mass General's procedure was able to prevent not only rejection of the transplanted kidney but graft vs host disease in this woman with multiple myeloma and kidney failure. It is almost a year since the "procedure, her kidneys are working, the myeloma is "nearly undetectable" and she is not taking immunosuppressive drugs. Just curious, in the 10 of 17 patients presented a few months ago and mentioned in the Forbes article, were the donors related to the recipients?

To: scaram(o)uche who wrote (371)	8/25/1999 10:35:00 AM
From: LLCF	Read Replies (2) \| Respond to of 1475

Rick, I'm a bit surprised with the muted response... I'm buying some more here... I know it's relatively early stage, but hell in human, and nice evidence. Given current mkt cap and the mkt for the process... I just don't get it. Are these guys waiting to look closer before the buy do you think???? Am I nuts for buyin at these levels? Dave

To: scaram(o)uche who wrote (371)	8/27/1999 6:29:00 PM
From: Ilaine	Read Replies (1) \| Respond to of 1475

Richard, curious as to where you got the information on the patent application. The USPTO web site says that patent application data is confidential. I wonder about the patentability of the procedure. Sykes, et al. can't patent bone marrow transplants, they are known. And they can't patent organ transplants, they, too, are known. They can't patent doing both at the same time if the procedures are medically indicated, as that would be obvious. The only thing they can patent is doing them at the same time for the purpose of making the recipient not reject the host organ, when the bone marrow transplant isn't otherwise needed, which could probably be patented, although enforcement seems problematic, BWDIK? What I heard on NPR was that they aren't planning on using the procedure for that purpose yet. I don't know about the relative risk ratios of bone marrow transplants vs. immunosuppressive drugs. But I am sure that on NPR they said this would only work with closely matched donors of bone marrow, in the case they were talking about on NPR, a sister. How often is it that an organ donor is closely matched? I think usually just for kidneys and bone marrow, right? Edit: just searched "mixed chimerism" on PubMed, 437 entries, so even that's going to be hard to patent.