To: scaram(o)uche who wrote (939 ) 9/27/1999 8:02:00 AM From: M. P. McNamara, Jr. M.D. Read Replies (2) | Respond to of 2001
Gliatech Announces Product Development Program for Schizophrenia Monday September 27, 6:30 am Eastern Time Company Press Release SOURCE: Gliatech Inc. CLEVELAND, Sept. 27 /PRNewswire/ -- Gliatech Inc. (Nasdaq: GLIA - news) announced today the initiation of product development programs for schizophrenia and dementia involving the regulation of human glycine transporters. In a recent article published in Molecular Brain Research, Gliatech scientists describe their identification of the gene sequences encoding the human glycine transporter type 2 (GlyT2). The glycine transporters, type 1 (GlyT1) and type 2 (GlyT2), regulate the neurotransmitter, glycine, in the brain and spinal cord. GlyT1 regulates the amount of the neurotransmitter glycine in the brain and plays an important role in learning and memory. Certain evidence indicates that GlyT1 may affect memory loss as well as certain symptoms associated with schizophrenia. GlyT2 regulates glycine in the spinal cord and affects muscle activity. Its inactivation leads to muscle spasticity and convulsions. Gliatech has initiated drug development programs aimed at developing novel inhibitors of these two glycine transporters. The Company has identified prototype inhibitors of GlyT1 and is investigating these and related compounds for their potential utility in the treatment of schizophrenia and dementia. ``The regulation of other neurotransmitters, such as serotonin and dopamine through the inhibition of their transporter systems has led to several successful pharmaceutical products,' said Thomas O. Oesterling, Ph.D., Chairman and Chief Executive Officer of Gliatech Inc. ``We believe that applying this strategy to the glycine transporter systems will lead to novel drug candidates that will be useful for several important clinical indications, such as schizophrenia, where there are 2.5 million cases diagnosed each year.' Gliatech was formed in 1988 to discover, develop and commercialize therapeutic products based on understanding the properties of glial cells, a major component of the nervous system. The Company applies its core glial research to developing innovative products for major unmet health care needs. Certain statements in this press release constitute ``forward-looking statements' that are subject to risks and uncertainties which may cause the actual results of the Company to be different from expectations expressed or implied by such forward-looking statements. Such factors include, but are not limited to, uncertainty of market acceptance of the Company's products, the uncertainty of the continued development of human glycine transporters, the uncertainty of the continued development of monoclonal antibodies and other risk factors detailed in the Company's SEC filings. SOURCE: Gliatech Inc.