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Biotech / Medical : Cistron Biotechnology(CIST)$.30 -- Ignore unavailable to you. Want to Upgrade?

To: Joe Wesley who wrote (2482)	9/27/1999 7:04:00 PM
From: Walter Morton	Respond to of 2742

I don't know. Steve Harmon may have the answer. I'm surprised that there was no 10-K news today. Only once in the past three years has CIST issued its 10-K on October 1st.

To: Joe Wesley who wrote (2482)	9/30/1999 1:52:00 PM
From: Walter Morton	Respond to of 2742

News: siliconinvestor.com

To: Joe Wesley who wrote (2482)	10/8/1999 1:22:00 AM
From: Walter Morton	Respond to of 2742

BACKGROUND & AIMS: Fas-mediated apoptosis is one of the major death processes of hepatocytes in liver diseases. The aim of this study was to determine whether interleukin (IL)-1beta regulates the Fas-mediated apoptotic process of differentiated hepatocytes in vivo. METHODS: IL-1beta was injected into Balb/cA mice 5 hours before lethal challenge with agonistic anti-Fas administration. Survival and hepatocyte apoptotic process of these mice were examined. RESULTS: IL-1beta pretreatment prolonged animal survival in a dose-dependent manner, and 500 ng of IL-1beta completely protected mice from lethality. Both serum alanine aminotransferase value and hepatic DNA fragmentation were significantly suppressed by IL-1beta pretreatment. IL-1beta affected neither hepatic distribution of anti-Fas antibody nor Fas expression levels on hepatocytes but significantly suppressed Fas-induced activation of hepatic caspase 3-like protease. Suppression of Fas-induced activation of the caspase by IL-1beta was diminished by coadministration with D-galactosamine and reversed by coinjection with an excess amount of uridine. CONCLUSIONS: These results suggest that IL-1beta suppresses Fas-mediated hepatocyte apoptosis by inducing molecule(s) that suppress the apoptosis control machinery upstream of caspase 3. This observation raises the possibility that IL-1beta acts as a negative regulator of Fas-mediated epatocyte apoptosis during liver injury. Gastroenterology, 117(3):661-8 1999 Sep Takehara T; Hayashi N; Tatsumi T; Kanto T; Mita E; Sasaki Y; Kasahara A; Hori M Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan.