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To: QuietWon who wrote (102226)10/6/1999 11:24:00 PM
From: Ron  Read Replies (1) | Respond to of 119973
 
ENMD: More heavy-duty cancer news from the New York Times'
Gina Kolata:
nytimes.com
The logic has long sounded so compelling that few have questioned it: A particular protein seeps out of the prostate of a man who has prostate cancer. The more of that protein in the bloodstream, then, the worse it must be for the cancer patient. But now a group of scientists at EntreMed, a biotechnology company in Rockville, Md., say the prostate protein -- prostate specific antigen, or
PSA -- may actually be used by the body to fight cancer. They say the protein appears to be an angiogenesis inhibitor, one of a class of compounds that cut off blood supplies to tumors, preventing them from growing.
The researchers' report appears in Wednesday's issue of The Journal of the National Cancer Institute, which published it with unusual speed, as an "accelerated discovery," because it included not just test-tube evidence but also animal data pointing to a conclusion that could, if it holds up, eventually lead to important insights into the biology, screening or even treatment of cancer, said Dr. Barnett Kramer, the journal's editor.
Prostate-cancer experts caution that the finding, while surprising and intriguing, does not mean that current methods of dealing with prostate cancer are misguided. Many questions remain as to whether PSA actually fights cancer, and any possible use of it as a treatment is still very much in the future.