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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?


To: Robert K. who wrote (12289)11/21/1999 12:14:00 PM
From: aknahow  Respond to of 17367
 
Thanks, I am disappointed that apparently no one asked for the slides to be faxed to them. Or am I the only klutz that is not set up to receive faxes? The significance of the decline in placebo negative events in the trauma trial seems lost on many posters. This is very important in terms of Neuprex. Certainly not a negative for Neuprex. Also, would have been very difficult for any management to anticipate. Yes with hindsight one can say trial should be run only on subjects that have a negative event already. Not on subjects that may develop problems as a result of loss of blood.



To: Robert K. who wrote (12289)11/21/1999 9:52:00 PM
From: Robert K.  Read Replies (3) | Respond to of 17367
 
From a probable independant source>
"BPI levels, but not LBP levels, progressively increased with storage time. In PCs with an age of 2 days, BPI levels averaged approximately 10 ng/mL, whereas in PCs of 31 days of age, BPI levels were approximately 50 ng/mL, suggesting disintegration of PMNs present in the packed cells." END
Further>
"Our present data are in support of this view inasmuch as they confirm the presence of large amounts of BPI in packed red cells. The transfusion of BPI by giving packed red cells to a patient actually leads to increased circulating plasma levels of BPI. It cannot be deduced from our present data that higher BPI levels cause an increased postoperative morbidity." End
Furthermore
"In the PCs, large amounts of BPI may be released from the azurophilic granules because of PMN activation by the plastic infusion bag or PMN disintegration as a result of cold storage (4øC)."
Now my question to you all is >what where the requirements for entry into the trauma trial? (It starts with a T)
Can anyone recall such a odd occurance? Was there a true placebo group? My words>"Maybe it is possible that the reason the placebo group did so well was that........" Almost unbelievable. The significance I do not know.
Better than the x files my friends.