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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: Bluegreen who wrote (12324)	11/23/1999 6:04:00 PM
From: Robert K.	Read Replies (2) \| Respond to of 17367

Yeah, thank goodness xoma had a trial going without transfusions.

To: Bluegreen who wrote (12324)	11/23/1999 7:28:00 PM
From: aknahow	Read Replies (2) \| Respond to of 17367

5990082 Must be NON NOVEL PATENT deals with LBP. Probably of no importance and no interest. SUMMARY OF THE INVENTION The present invention is based on the discovery that lipopolysaccharide binding protein (LBP), an agent previously thought to be stimulatory of the adverse effects of bacteria and their endotoxin, can actually reduce the inflammatory potential of bacteria and their endotoxin when administered to certain subjects prior to exposure to the bacterial endotoxin. In particular, the invention relates to the administration of LBP in an amount effective to inhibit the adverse effects of bacterial endotoxin to a subject who has a circulating level of LBP in the normal range as measured by a quantitative LBP assay. The LBP is administered at a time prior to exposure to bacterial endotoxin (i.e., when the subject will be at risk of such exposure). Such times of "at risk of exposure to endotoxin" include circumstances or conditions associated with increased translocation of gut associated bacteria and endotoxin, particularly prior to surgery. Thus, these subjects are administered prophylactic doses of LBP, to raise the circulating LBP levels to therapeutically effective amounts, in advance of exposure to bacterial endotoxin. The invention thus provides a method of protection against the adverse effects of bacterial endotoxin at a time prior to endotoxin challenge/exposure.