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Biotech / Medical : XOMA. Bull or Bear? -- Ignore unavailable to you. Want to Upgrade?

To: aknahow who wrote (12444)	12/13/1999 11:00:00 PM
From: Bluegreen	Respond to of 17367

Bad news just in from across the pond....was on BBC website. George how many more Babies have to die? No one speaks for the kids. We now know that neonates don't have enough BPI. Hopefully the Harvard people will move the ball forward.>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>> Meningitis claims one-year-old boy A baby boy died of meningitis just a day after his first birthday party. Ben Gill from Yorkshire was taken to hospital by his parents, who feared he had meningitis after carrying out the "glass test" on blotches on the baby's skin. Despite help from specialists from Leeds and Manchester, staff at Pinderfields Hospital in Wakefield could do nothing to save him and he died last Saturday. Anne Gibson, at Wakefield Health Authority, warned parents of babies and children under two to be particularly vigilant over winter months. "Symptoms to look out for in young children are a fever, repeated vomiting and the rash which if you press it does not go away," she said. A spokeswoman for the Meningitis Research Foundation said: "Parents know the child better than anyone else - if you are worried, get medical advice."<<<<<<<<<<<<<<<<<<

To: aknahow who wrote (12444)	12/14/1999 10:14:00 PM
From: Bluegreen	Read Replies (2) \| Respond to of 17367

UNBELIEVABLE!!!!!! JUST UNBELIEVABLE!!!!!!! >>>>>>>>>>>>Protein Sci 1999 Nov;8(11):2392-8 Immunochemical evidence that cholesteryl ester transfer protein and bactericidal/permeability-increasing protein share a similar tertiary structure. Guyard-Dangremont V, Tenekjian V, Chauhan V, Walter S, Roy P, Rassart E, Milne AR Department of Pathology and Biochemistry, University of Ottawa Heart Institute, Ontario, Canada. Cholesteryl ester transfer protein (CETP) plays an important role in plasma lipoprotein metabolism through its ability to transfer cholesteryl ester, triglyceride, and phospholipid between lipoproteins. CETP is a member of a gene family that also includes bactericidal/permeability-increasing protein (BPI). The crystal structure of BPI shows it to be composed of two domains that share a similar structural fold that includes an apolar ligand-binding pocket. As structurally important residues are conserved between BPI and CETP, it is thought that CETP and BPI may have a similar overall conformation. We have previously proposed a model of CETP structure based on the binding characteristics of anti-CETP monoclonal antibodies (mAbs). We now present a refined epitope map of CETP that has been adapted to a structural model of CETP that uses the atomic coordinates of BPI. Four epitopes composed of CETP residues 215-219, 219-223, 223-227, and 444-450, respectively, are predicted to be situated on the external surface of the central beta-sheet and a fifth epitope (residues 225-258) on an extended linker that connects the two domains of the molecule. Three other epitopes, residues 317-331, 360-366, and 393-410, would form part of the putative carboxy-terminal beta-barrel. The ability of the corresponding mAbs to compete for binding to CETP is consistent with the proximity of the respective epitopes in the model. These results thus provide experimental evidence that is consistent with CETP and BPI having similar surface topologies.<<<<<<<<<<<