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To: Jim Bishop who wrote (20673)1/19/2000 9:38:00 AM
From: SSP  Respond to of 150070
 
The Lists, goldenlists.com
Symbol Last Change Net Chg. % Tot. Vol. Company Name
KLYS .22000 +.10000 +83.33 63800 KELLY
CECS .115000 +.01500 +15.00 30000 CHOICES ENTERTAINMENT CORP
AQCB .1750 +.0225 +14.75 6300 AQUA CLARA BOTTLING
HICS 1.95000 +.21000 +12.07 5200 HYDROGIENE CORP
KAHI .44000 +.04000 +10.00 154800 KAIRE HOLDINGS INC
UVGI .23750 +.01450 +6.50 11700 UNITED VENTURES GROUP INC
PFCK .73500 +.03500 +5.00 11100 PEACOCK FINANCIAL CORP.
OGPS .87500 +.03130 +3.71 4000 OMICRON TECHNOLOGIES CORP
TRAC 7 21/32 +7/32 +2.94 86700 TRACK DATA CORPORATION
PUMA 92 9/16 +1/16 +.07 8700 PUMA TECHNOLOGY, INC.
ECO 1 3/8 +0 24400 ECHO BAY MINES LTD.
PCES 0 +0 PACE HEALTH MGMT. SYSTEMS
CCCZ 0 +0 CASTELLO CASINO CORP, COM NEW
ADVA 0 +0 ADVANCED MEDICAL PRODUCTS INC, COM N
CHIP 0 +0 LS CAPITAL CORPORATION
SGNC 0 +0 SANGUINE CORPORATION
DANS 0 +0 DANSKIN, INC.
FCM 0 +0 FRANKLIN TELECOMMUNS CORP
VXCL 0 +0 VAXCEL, INC.
IRTG 0 +0 IRT INDUSTRIES, INC.
LOCH .5400 -.0050 -.92 129400 LOCH HARRIS INC, SHS
ONIN 5.00000 -.25000 -4.76 1000 ONLINE INNOVATION INC
EGEI .0550 -.0050 -8.33 34500 ENG ENTERPRISES INC



To: Jim Bishop who wrote (20673)1/19/2000 9:45:00 AM
From: SSP  Respond to of 150070
 
Geron Corporation Announces Issuance of Nuclear Transfer Patents


Medical & Health Writers

MENLO PARK, Calif.--(BW HealthWire)--January 19, 2000--Geron
Corporation (Nasdaq:GERN) announced today the issuance of two U.K.
patents covering nuclear transfer technology. Geron also announced
that the U.S. Patent Office has issued a Notice of Allowance for a
U.S. patent application encompassing the same technology.
The patents cover nuclear transfer technology using donor nuclei
from quiescent cells. This technology was developed by Drs. Keith
Campbell and Ian Wilmut at the Roslin Institute in Edinburgh, Scotland
("Roslin") and was used to produce Dolly, the cloned sheep. The same
technology has subsequently been used successfully by a number of
other research groups to produce cloned mammals. The patents and the
underlying technologies are licensed to Geron from Roslin for a wide
range of applications, including use in human regenerative medicine
and animal cloning. The license rights, which were obtained as part of
Geron's acquisition of Roslin Bio-Med Ltd. (now Geron Bio-Med Ltd.)
from Roslin, include rights to the "quiescence" and "MAGIC" nuclear
transfer technologies, as well as intellectual property arising from
Geron's ongoing funding of research at Roslin.
The first U.K. patent, patent number GB 2318578, has 31 claims
directed to methods of nuclear transfer. The claims include broad
generic claims to methods of nuclear transfer in which the nucleus of
a quiescent donor cell is transferred into a suitable recipient cell.
The claims specifically cover instances where scientists might use a
somatic cell as the nuclear donor. The patent also covers methods of
producing cloned non-human animals and methods of producing animal
(i.e., human and non-human) cells by nuclear transfer. This is
consistent with a joint recommendation of the U.K. Human Fertilisation
and Embryology Authority and the Human Genetics Advisory Committee
that human therapeutic cloning should be added as a permitted area of
embryo research under U.K. law. This recommendation is currently under
review.
The second U.K. patent, patent number GB 2331751, has 28 claims
directed to compositions of matter. The claims of this patent include
claims to non-human animal embryos and cloned non-human animals
produced using nuclear transfer. In addition, the patent covers
non-human and human cell lines made using this technology. Both of the
U.K. patents have a priority date of August, 1995.
The allowed U.S. application includes claims pertaining to the
use of the nuclear transfer technology to produce cloned non-human
mammals, including cattle, sheep, goats and pigs. The claims also
cover the use of this technology to produce cell lines. Geron will
provide further information concerning this allowed application upon
issuance of the patent.
"These are the first patents to issue from Geron's international
portfolio of intellectual property directed to nuclear transfer,"
commented David J. Earp, J.D., Ph.D., Geron's vice president of
intellectual property. "The claims of these patents cover the most
fundamental aspects of the quiescence technology. We will continue to
expand our proprietary position in this field with additional patent
filings for this and other aspects of nuclear transfer technology,
including MAGIC."
Thomas Okarma, Ph.D., M.D., Geron's president and chief executive
officer noted that the patents represent a multi-faceted asset for
Geron: "We expect the nuclear transfer technology to be of significant
value in Geron's regenerative medicine program, which is focused on
producing cells and tissues in vitro for treatment of a wide range of
degenerative diseases. The integration of nuclear transfer with our
pluripotent stem cell and telomerase immortalization technologies may
allow the in vitro production of replacement cells and tissues that
would not be rejected by the patient's immune system. This would be a
major advance for medicine because it could eliminate the need for
toxic immunosuppressive drugs that are typically needed with
conventional transplantation. Because the patent coverage extends to
the use of the technology in human cells, it provides Geron with the
lead proprietary position for such human regenerative medicine
techniques."
"In addition," he noted, "the patents cover the use of the
technology for animal cloning. There is currently much interest in
animal cloning technology for agricultural uses -- for example, to
preserve high-performing or rare animals for use in breeding programs
-- as well as in the pharmaceutical industry, where transgenic animals
might be used to produce medicines or organs for human use. The
combination of the intellectual property asset that we are announcing
today, together with our ongoing collaboration with the Roslin
Institute, places Geron in a strong position to develop the technology
for such applications."
These patents and the underlying technologies are licensed to
Geron for all applications with one exception: PPL Therapeutics Ltd.
holds a license to use the technology for producing human proteins in
the milk of ruminants and rabbits for pharmaceutical and nutraceutical
uses. In addition, the license prohibits use of the technology for
human reproductive cloning. Geron fully supports the ban on human
reproductive cloning.
Geron Corporation is a biopharmaceutical company focusing on
discovering, developing and commercializing therapeutic and diagnostic
products to treat cancer and other age-related chronic degenerative
diseases. Geron's technology platform includes the discovery of small
molecule inhibitors of telomerase for cancer therapy; telomere and
telomerase-based research and diagnostic tools; telomerase activation
to extend the replicative lifespan of normal cells; and complementary
stem cell, gene therapy and nuclear transfer approaches to restore the
function of degenerating organs.
Statements in this press release regarding product development
and future applications of Geron's technology constitute
forward-looking statements that are subject to certain risks and
uncertainties. Actual results may differ materially from the results
anticipated in these forward-looking statements. Additional
information on potential factors that could affect the company's
results is included in the company's quarterly report on Form 10-Q for
the quarter ended September 30, 1999.
To receive an index and copies of recent press releases, call
Geron's News On Demand toll-free fax service, 800/782-3279. Additional
information about Geron Corporation can be obtained at
geron.com.

--30--ma/sf* eb/sf

CONTACT: Geron Corporation
Nancy Robinson, 650/473-7700 (Investors & Media )
Dennis Schwartz, New York
Burns McClellan, 212/213-0006 (Investor Inquiries)



To: Jim Bishop who wrote (20673)1/19/2000 9:55:00 AM
From: SSP  Respond to of 150070
 
ABRG - continuing to gain - .057x.06 and I expect a LOT more!