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Biotech / Medical : Biotech Valuation -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (533)	1/23/2000 11:40:00 AM
From: aknahow	Respond to of 52153

Interesting fresh article on small molecules especially for people like me without great, (any), knowledge in this area. biomednet.com Snip>>>>>>>>>>>>> PROFILE Getting Rid of Radicals MetaPhore Pharmaceuticals, Inc. by William A. Wells Reprinted with permission from Chemistry & Biology. Posted January 21, 2000 ú Issue 70 Abstract Small molecules that mimic enzymes can destroy radicals - those reactive nasties that might just kill you. Modern molecular biology is geared towards genes and proteins, with small molecule chemistry coming in a distant third. Small molecules are important as drugs, but largely ignored in understanding how the cell works. SNIP>>>>>>>>>>>>>>>>

To: scaram(o)uche who wrote (533)	1/23/2000 3:12:00 PM
From: A.J. Mullen	Read Replies (1) \| Respond to of 52153

Why should competition for the health-care dollar encourage small molecule drugs? I imagine large molecules might cost more to produce, but that those costs are still small compared to R&D. Perhaps with many good drugs coming to market and competing, the effective royalty rate will be depressed, and this would increase the significance of costs production. Is that your reasoning? Wouldn't drugs still compete largely on grounds of effectiveness? If so, the argument that large-molecule drugs are better targeted would suggest they could be the most effective. Or is it a fallacy that large molecule drugs are better targeted? Ashley