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Biotech / Medical : Vertex Pharmaceuticals (VRTX) -- Ignore unavailable to you. Want to Upgrade?

To: Miljenko Zuanic who wrote (389)	2/8/2000 8:54:00 PM
From: Miljenko Zuanic	Read Replies (1) \| Respond to of 1169

Just parking, Medline search for P38 + COX-2 + prostaglandin. BTW, did anyone have info on what Company presented to healthy investors at M. L. conference today? Miljenko 1 Guan Z, et al; Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1/MKK4 --> p38 mitogen-activated protein kinase pathway. (J Biol Chem, 1998 May, Abstract available) [MEDLINE] 2 LaPointe MC, et al; Interleukin-1beta regulation of inducible nitric oxide synthase and cyclooxygenase-2 involves the p42/44 and p38 MAPK signaling pathways in cardiac myocytes. (Hypertension, 1999 Jan, Abstract available) [MEDLINE] 3 Bartlett SR, et al; Induction of cyclooxygenase-2 expression in human myometrial smooth muscle cells by interleukin-1beta: involvement of p38 mitogen-activated protein kinase. (J Physiol (Lond), 1999 Oct, Abstract available) [MEDLINE] 4 Guan Z, et al; Interleukin-1beta-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. (J Biol Chem, 1998 Oct, Abstract available) [MEDLINE] 5 Niiro H, et al; MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes. (Biochem Biophys Res Commun, 1998 Sep, Abstract available) [MEDLINE] 6 Barry OP, et al; Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. (J Biol Chem, 1999 Mar, Abstract available) [MEDLINE] 7 Subbaramaiah K, et al; Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways. (J Biol Chem, 1998 Dec, Abstract available) [MEDLINE] 8 Jones MK, et al; HGF triggers activation of the COX-2 gene in rat gastric epithelial cells: action mediated through the ERK2 signaling pathway. (FASEB J, 1999 Dec, Abstract available) [MEDLINE] 9 Chen CC, et al; Role of the cyclic AMP-protein kinase A pathway in lipopolysaccharide-induced nitric oxide synthase expression in RAW 264.7 macrophages. Involvement of cyclooxygenase-2. (J Biol Chem, 1999 Oct, Abstract available) [MEDLINE] 10 Lin WW, et al; Induction of cyclo-oxygenase-2 expression by methyl arachidonyl fluorophosphonate in murine J774 macrophages: roles of protein kinase C, ERKs and p38 MAPK. (Br J Pharmacol, 1999 Mar, Abstract available) [MEDLINE] 11 Pouliot M, et al; Monosodium urate microcrystals induce cyclooxygenase-2 in human monocytes. (Blood, 1998 Mar, Abstract available) [MEDLINE]