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Biotech / Medical : ARIAD Pharmaceuticals -- Ignore unavailable to you. Want to Upgrade?

To: Pseudo Biologist who wrote (998)	2/5/2000 8:48:00 AM
From: scott_jiminez	Respond to of 4474

While there certainly is a class of glucose-specific transporters (the 'GLUTs'), your response gets to the heart of why my suggestion is probably implausible (and believe me, my cell biology is no better than yours). Not only would transport need to be invoked (as opposed to the cell-permeability of the dimerizer), but the potential 'interference' (for lack of a better word) of a changing gluconeogenesis/glycolysis balance following glucose uptake would probably significantly distort the entire RAPID system. Thus the rapidity of the response of Ariad's construct would likely be greatly compromised. In short (!, and as you said in 2-3 short sentences as compared to my +++++), things would definitely get a lot more complicated...even IF transport is not a rate-limiting factor. Most importantly, I really don't care to be reading THIS particular section of Alberts et al. ncbi.nlm.nih.gov:80/books/mboc/mboc.cgi?code=0205031724202093 nor did I ever want to stare at these flow charts again ncbi.nlm.nih.gov:80/books/mboc/mboc.cgi?action=figure&fig=2-40