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Biotech / Medical : Cadus Pharmaceutical Corp. (KDUS) -- Ignore unavailable to you. Want to Upgrade?

To: scaram(o)uche who wrote (123)	3/9/2000 10:47:00 AM
From: scaram(o)uche	Read Replies (1) \| Respond to of 1833

Don't remember having posted this before, please excuse duplication if I have. Priority date appears to be 4/26/94..... Inventor(s): Broach; James R. , Princeton, NJ Manfredi; John P. , Ossining, NY Trueheart; Joshua , Nyack, NY Applicant(s): Cadus Pharmaceutical Corporation, Tarrytown, NY Issued/Filed Dates: Dec. 14, 1999 / Jan. 14, 1997 Application Number: US1997000732218 Abstract: Mammalian adenylyl cyclases are functionally expressed in yeast cells. The yeast cells may be used to screen for inhibitors or activators of the adenylyl cyclase, or of a regulator of adenylyl cyclase which is functionally co-expressed in the yeast cell. Methods of identifying such inhibitors, activators and regulators are also disclosed. We claim: 1. A haploid yeast cell engineered to express a mammalian adenylyl cyclase and a mammalian or chimeric G protein subunit, said mammalian adenylyl cyclase being functional and regulatable in said cell even in the absence of expression of a mammalian G protein-coupled receptor by the yeast cell.