Silicon Investor (SI) -- The First Internet Community

STOCKTALK

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor. We ask that you disable ad blocking while on Silicon Investor in the best interests of our community. If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.

Biotech / Medical : T/FIF, a New Plateau -- Ignore unavailable to you. Want to Upgrade?

To: biowa who wrote (53)	3/20/2000 12:45:00 PM
From: Jim Oravetz	Read Replies (1) \| Respond to of 2243

Protemics: Axcell division of Cytogen(CYTO) Message 13240694 I would appreciate some comments on the US Patent 6,011,137. It appears to me that they have some unique protein discovery methods. From 3. SUMMARY OF THE INVENTION ...The present invention also provides methods for identifying potential new drug candidates (and potential lead compounds) and determining the specificities thereof. For example, knowing that a polypeptide with a WW domain and a recognition unit, e.g., a binding peptide, exhibit a selective affinity for each other, one may attempt to identify a drug that can exert an effect on the polypeptide-recognition unit interaction, e.g., either as an agonist or as an antagonist (inhibitor) of the interaction. With this assay, then, one can screen a collection of candidate "drugs" for the one exhibiting the most desired characteristic, e.g., the most efficacious in disrupting the interaction or in competing with the recognition unit for binding to the polypeptide. In addition, the present invention also provides certain assay kits and methods of using these assay kits for screening drug candidates. In a particular aspect of the present invention, the assay kit comprises: (a) a polypeptide containing a WW domain; and (b) a recognition unit having a selective affinity for the polypeptide. Yet another assay kit may comprise a plurality of polypeptides, each polypeptide containing a WW domain, preferably of a different sequence, and at least one recognition unit having a selective affinity for each of the plurality of polypeptides. snip.... Jim