To: scaram(o)uche who wrote (454 ) 4/17/2000 5:00:00 PM From: scaram(o)uche Read Replies (1) | Respond to of 805
10-K out...... The following table lists the potential therapeutic indications for and current status of CytoTherapeutics' primary research and product development programs and projects and is qualified in its entirety by reference to the more detailed descriptions of such programs and projects appearing elsewhere in this Report. The Company continually evaluates its research and product development efforts and reallocates resources among existing programs or to new programs in light of experimental results, commercial potential, availability of third party funding, likelihood of near-term efficacy, collaboration success or significant technology enhancement, as well as other factors. The Company's research and product development programs are at relatively early stages of development and will require substantial resources to commercialize. There can be no assurance that the Company will successfully develop any product or obtain regulatory approvals, enter clinical trials, achieve other milestones or commercialize any products in accordance with currently anticipated timetables, or at all. <TABLE> RESEARCH AND PRODUCT DEVELOPMENT PROGRAMS PROGRAM DESCRIPTION STAGE/STATUS(1) <S> <C> HUMAN NEURAL STEM CELL PRECLINICAL Repair or replace damaged CNS - IN VITRO ability to initiate and expand stem tissue (including retinal cell-containing human neural cultures and differentiation degeneration and the results into three types of CNS cells of certain genetic disorders) - Direct isolation of neurosphere-initiating stem cells from brain - IN VIVO demonstration of proper differentiation and engraftment of human neural cell cultures containing CNS stem cells in rodent CNS PANCREATIC ISLET STEM CELL RESEARCH Repair or replace damaged - Identified cell surface marker used to identify, isolate pancreatic islet tissue and culture pancreatic islet stem cells - Commencing small animal testing LIVER STEM CELL RESEARCH Repair or replace damaged Discovery program to identify, isolate and patent human stem liver tissue (including the cells for the liver results of certain metabolic genetic diseases) </TABLE> (1) "Research" refers to early stage research and product development activities IN VITRO, including the selection and characterization of product candidates for preclinical testing. "Preclinical" refers to further testing of a defined product candidate IN VITRO and in animals prior to clinical studies.